The Philippine Science High School (PSHS) offers on, a scholarship basis, a secondary course with special emphasis on subjects pertaining to the sciences with the view of preparing its students for a science career.

The Philippine Textile Research Institute (PTRI) conducts applied research and development for the textile industry sector. In fulfilling this mandate, it undertakes the transfer of completed researches to end-users or via linkage units of other government agencies. It provides technical services and conducts training programs on the concerns of the sector.

The Science Education Institute (SEI) formulates plans and establishes programs and projects for the promotion and development of science and technology education and training in the field of science and technology in coordination with other institutions of learning. It undertakes science and technology manpower development and administers scholarships, awards, and grants.

The Science and Technology Information Institute (STII) takes the lead in information science and technology training. It establishes and maintains a science and technology databank and library, and disseminates science and technology information.

The Technology Application and Promotion Institute (TAPI) is the implementing arm of DOST in promoting the commercialization of technologies and in marketing the services of the other operating units of the Department. It undertakes contract research, particularly at pilot plant and semi-commercial stage; provides technical consultancy, including engineering design services, patenting and licensing services; and provides grants and/or venture financing for new and emerging projects. It administers the Invention Development Assistance Fund (IDAF) for the initial experiments and prototype development and other invention development-related activities, and the Inventors Guarantee Fund (IGF) for assisting inventors in the development and commercialization of inventions.